Cancer Gene Therapy
Researchers from Roswell Park Cancer Institute, Department of Immunology detail new studies and findings in the area of cancer gene therapy
Published in Gene Therapy Weekly, March 15th, 2007
Researchers detail in "Dampening of IFN-gamma-inducible gene expression in human choriocarcinoma cells is due to phosphatase-mediated inhibition of the JAK/STAT-1 pathway," new data in cancer gene therapy. "Trophoblast cells (TBCs) form the blastocyst-derived component of the placenta and play essential roles in fetal maintenance. The proinflammatory cytokine IFN-gamma plays a central role in activating cellular immunity, controlling cell proliferation, and inducing apoptosis," investigators in the United States report.
"IFN-gamma is secreted by uterine NK cells in the placenta during pregnancy and in mice is required for proper formation of the decidual layer and...
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Source: Gene Therapy Weekly (2007-03-15)
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