Gene Therapy

Study findings on gene therapy are outlined in reports from Beth Israel Deaconess Medical Center, Division of Vascular Surgery

Published in Gene Therapy Weekly, March 22nd, 2007

New research, "A novel function for cadherin 11/osteoblast-cadherin in vascular smooth muscle cells: modulation of cell migration and proliferation," is the subject of a report. According to recent research from the United States, "Intimal hyperplasia is a common cause of vein graft failure in cardiovascular surgery. The molecular basis for intimal hyperplasia remains poorly defined."

"We have previously identified, by gene chip analysis of vein grafts, increased messenger (mRNA) for the adhesion molecule cadherin 11/osteoblast-cadherin (CDH11). The function of CDH11 in vascular cells is unknown. The aim of the present study is to confirm CDH11 expression in vein grafts...

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Source: Gene Therapy Weekly (2007-03-22)

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