Reports from Center of Molecular and Macromolecular Studies add new data to research in gene therapy

New investigation results, "Mapping of the functional phosphate groups in the catalytic core of deoxyribozyme 10-23," are detailed in a study published in FEBS Journal. According to recent research published in the FEBS Journal, "The RNA phosphodiester bond cleavage activity of a series of 16 thio-deoxyribozymes 10-23, containing a P-stereorandom single phosphorothioate linkage in predetermined positions of the catalytic core from P1 to P16, was evaluated under single-turnover conditions in the presence of either 3 mM Mg(2+) or 3 mM Mn(2+). A metal-specificity switch approach permitted the identification of nonbridging phosphate oxygens (proR(P) or proS(P)) located at seven...

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