Gene Therapy
Research from Gunma University, Institute for Molecular and Cellular Regulation in the area of gene therapy published
Published in Gene Therapy Weekly, March 22nd, 2007
Research findings, "In vitro transdifferentiation of mature hepatocytes into insulin-producing cells," are discussed in a new report. According to a study from Maebashi, Japan, "Adenovirus-mediated gene transfer of pancreatic duodenal homeobox transcription factor PDX-1, especially its super-active version (PDX-1/VP16), induces the expression of pancreatic hormones in murine liver and reverses streptozotocin-induced hyperglycemia. Histological analyses suggest that hepatocytes are the major source of insulin-producing cells by PDX-1 gene transfer, although the conversion of cultured hepatocytes into insulin-producing cells remains to be elucidated."
"The present study...
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Source: Gene Therapy Weekly (2007-03-22)
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