Prodrugs
Researchers from Georgia State University, Department of Biology provide details of new studies and findings in the area of prodrugs
Published in Gene Therapy Weekly, April 12th, 2007
Scientists discuss in "Crystal structure of the Geobacillus stearothermophilus carboxylesterase Est55 and its activation of prodrug CPT-11" new findings in prodrugs. "Several mammalian carboxylesterases were shown to activate the prodrug irinotecan (CPT-11) to produce 7-ethyl-10-hydroxycamptothecin (SN-38), a topoisomerase inhibitor used in cancer therapy. However, the potential use of bacterial carboxylesterases, which have the advantage of high stability, has not been explored," scientists writing in the journal JMB Online report.
"We present the crystal structure of the carboxyesterase Est55 from Geobacillus stearothermophilus and evaluation of its enzyme...
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Source: Gene Therapy Weekly (2007-04-12)
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