Gene Therapy

Data on gene therapy published by researchers at Osaka City University, Department of Gastroenterology

Published in Gene Therapy Weekly, April 12th, 2007

Investigators publish new data in the report "Growth inhibition of colon cancer cells by transfection of dominant-negative apoptosis signal-regulating kinase-1." According to a study from Osaka, Japan, "Apoptosis signal-regulating kinase-1 (ASK-1) is an important molecule for the pro-apoptotic signaling. ASK-1 also contributes to the cellular survival for many types of cells."

"Thus, ASK-1 has a broad range of biological activities depending on the cell type. The present study assessed the role(s) of ASK-1 in colorectal cancer cells (HT-29) by using adenovirus vectors expressing wild-type (WT)-ASK-1 or dominant-negative (DN) mutant of ASK-1 and recombinant adenovirus...

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Source: Gene Therapy Weekly (2007-04-12)

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