Gene Therapy

Research from University of Montreal reveals new findings on gene therapy

Published in Gene Therapy Weekly, April 12th, 2007

New research, "RNA interference targeting alpha8 integrin attenuates smooth muscle cell growth," is the subject of a report. According to recent research published in the journal FEBS Letters, "Alpha8 integrin gene silencing has been shown to result in the stress fibre disassembly. Stress fibres are required for cell adhesion to promote passage through cell cycle."

"Thus, we hypothesized that alpha8 integrin gene silencing might affect vascular smooth muscle cell (VSMC) growth. Short interference RNA (siRNA) targeting alpha8 integrin in rat VSMCs resulted in reduced DNA synthesis. Moreover, siRNA-alpha8 integrin prevented thrombin-induced proliferation. RhoA...

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Source: Gene Therapy Weekly (2007-04-12)

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