Gene Therapy
Investigators at University of York, Department of Biology release new data on gene therapy
Published in Gene Therapy Weekly, April 19th, 2007
New research, "Trypanosoma brucei ARF1 plays a central role in endocytosis and golgi-lysosome trafficking," is the subject of a report. According to a study from Heslington, the United Kingdom, "The ADP ribosylation factor (Arf)1 orthologue in the divergent eukaryote Trypanosoma brucei (Tb) shares characteristics with both Arf1 and Arf6 and has a vital role in intracellular protein trafficking. TbARF1 is Golgi localized in trypanosomes but associates with the plasma membrane when expressed in human cells."
"Depletion of TbARF1 by RNA interference causes a major decrease in endocytosis, which correlates with Rab5 dissociation from early endosomes. Although the...
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Source: Gene Therapy Weekly (2007-04-19)
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