Gene Therapy
Iowa State University details research in gene therapy
Published in Gene Therapy Weekly, April 26th, 2007
A report, "Investigation of in vitro biocompatibility of novel pentablock copolymers for gene delivery," is newly published data in Journal of Biomedical Materials Research Part A. "Novel pentablock copolymers of poly(diethylaminoethylmethacrylate) (PDEAEM), poly(ethylene oxide) (PEO), and poly(propylene oxide) (PPO), (PDEAEM-b-PEO-b-PPO-b-PEO-b-PDEAEM), were synthesized as vectors for gene delivery, and were tested for their biocompatibility on SKOV3 (human ovarian carcinoma) and A431 (human epidermoid cancer) cell lines under different in vitro conditions using various assays to elucidate the mechanism of cell death. These copolymers form micelles in aqueous solutions and can be...
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Source: Gene Therapy Weekly (2007-04-26)
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