Gene Therapy
New gene therapy research from Kyoto Institute of Technology, Department of Applied Biology described
Published in Gene Therapy Weekly, May 3rd, 2007
A report, "Transcriptional regulation of the Drosophila rfc1 gene by the DRE-DREF pathway," is newly published data in FEBS Journal. According to a study from Japan, "The DNA replication-related element (DRE) is a common 8-bp sequence (5'-TATCGATA) found in the promoters of many DNA replication-related genes, to which DRE-binding factor (DREF) specifically binds to activate transcription. Replication factor C (RFC) is an essential five-subunit complex in DNA replication, the largest subunit being RFC140."
"We first identified the gene (rfc1) encoding the Drosophila RFC140 (dRFC140) protein and then isolated a mutant. The phenotypes suggested that the gene is...
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Source: Gene Therapy Weekly (2007-05-03)
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