Gene Therapy
New research on gene therapy from Musculoskeletal Disease Center summarized
Published in Gene Therapy Weekly, May 3rd, 2007
New investigation results, "Modifications of the fibroblast growth factor-2 gene led to a marked enhancement in secretion and stability of the recombinant fibroblast growth factor-2 protein," are detailed in a study published in Journal of Cellular Biochemistry. According to recent research from the United States, "Progress in FGF-2 gene therapy has been hampered by the difficulty in achieving therapeutic levels of FGF-2 secretion. This study tested whether the addition of BMP2/4 hybrid secretion signal to the FGF-2 gene and mutation of cys-70 and cys-88 to serine and asparagine, respectively, would increase the stability and secretion of active FGF-2 protein in mammalian cells...
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Source: Gene Therapy Weekly (2007-05-03)
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