Gene Therapy

Research reports from University of California provide new insights into gene therapy

Published in Gene Therapy Weekly, May 3rd, 2007

Researchers detail in "Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing," new data in gene therapy. According to a study from the United States, "Argonautes (AGOs) are conserved proteins that contain an RNA-binding PAZ domain and an RNase H-like PIWI domain. In Arabidopsis, except for AGO1, AGO4 and AGO7, the roles of seven other AGOs in gene silencing are not known."

"We found that a mutation in AGO6 partially suppresses transcriptional gene silencing in the DNA demethylase mutant ros1-1. In ago6-1ros1-1 plants, RD29A promoter short interfering RNAs (siRNAs) are less abundant, and cytosine methylation at both transgenic...

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Source: Gene Therapy Weekly (2007-05-03)

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