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Cancer Gene Therapy

Studies from University of Rochester, Department of Urology in the area of cancer gene therapy published

Published in Gene Therapy Weekly, May 10th, 2007

Current study results from the report, "The therapeutic and preventive effect of RRR-alpha-vitamin E succinate on prostate cancer via induction of insulin-like growth factor binding protein-3," have been published. "Insulin-like growth factor binding protein-3 (IGFBP-3) is a well-known antiproliferative and proapoptotic molecule in prostate cancer, suggesting that targeting IGFBP-3 might produce clinical benefits. In prostate cancer cells, RRR-alpha-vitamin E succinate (VES) inhibits cell proliferation and induces apoptosis, yet the mechanisms remain to be elucidated," investigators in the United States report.

"We hypothesize that the protective effects of VES in...

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