Glioblastoma Cell Biology
Research conducted at University of Toledo has provided new information about glioblastoma cell biology
Published in Gene Therapy Weekly, May 24th, 2007
A new study, "Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways," is now available. According to a study from the United States, "Expression of activated H-Ras induces a unique form of non-apoptotic cell death in human glioblastoma cells and other specific tumor cell lines. The major cytopathological features of this form of death are the accumulation of large phase-lucent, LAMP1-positive, cytoplasmic vacuoles."
"In this study we sought to determine if induction of cytoplasmic vacuolation a) depends on Ras farnesylation, b) is specific to H-Ras, and c) is mediated by signaling through the major known...
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Source: Gene Therapy Weekly (2007-05-24)
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