Gene Therapy
Research findings from Pennsylvania State University update understanding of gene therapy
Published in Gene Therapy Weekly, May 24th, 2007
New research, "Deamination-independent inhibition of hepatitis B virus reverse transcription by APOBEC3G," is the subject of a report. "The APOBEC3 family of mammalian cytidine deaminases, including APOBEC3G (A3G), has been shown to function as innate antiviral factors against retroviruses and can also suppress the replication of the hepatitis B virus (HBV). The mechanism by which A3G inhibits HBV replication remains to be elucidated," researchers in the United States report.
"In this study, we show that the inhibitory effect of APOBEC3 proteins on HBV replication was mainly at the DNA level, with only a minor effect on viral RNA packaging. The anti-HBV effect of A3G...
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Source: Gene Therapy Weekly (2007-05-24)
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