Gene Therapy

Avecia OligoMedicines Expands Manufacturing Capabilities for Aptamers and siRNA

Published in Gene Therapy Weekly, May 31st, 2007

Avecia OligoMedicines announced the further expansion of its Milford, MA manufacturing facility, dramatically enhancing the company's capabilities in siRNA and Aptamer manufacturing. The new equipment and facilities will be fully on line by 1 September 2007. The facility upgrade is in three key areas: Cleavage / Deprotection, Chromatography and Duplexation / Conjugation.

The chemistry deployed for RNA cleavage and deprotection is more complex and hazardous than that used for DNA manufacture. Avecia has installed new large scale cleavage deprotection vessels and equipment to enable large scale siRNA manufacture in batch sizes of 75-100mmol.

The...

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Source: Gene Therapy Weekly (2007-05-31)

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