Gene Therapy
Research from University of Melbourne in the area of gene therapy published
Published in Gene Therapy Weekly, June 7th, 2007
Research findings, "Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production," are discussed in a new report. "RNA interference (RNAi) is now widely used for gene silencing in mammalian cells. The mechanism uses the RNA-induced silencing complex, in which Dicer, Ago2, and the human immunodeficiency virus type 1 (HIV-1) TAR RNA binding protein (TRBP) are the main components," scientists in Parkville, Australia report.
"TRBP is a protein that increases HIV-1 expression and replication by inhibition of the interferon-induced protein kinase PKR and by...
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Source: Gene Therapy Weekly (2007-06-07)
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