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Gene Therapy

Reports from University of Copenhagen advance knowledge in gene therapy

Published in Gene Therapy Weekly, June 14th, 2007

New investigation results, "Identification of a novel human glucagon receptor promoter: regulation by cAMP and PGC-1alpha," are detailed in a study published in Gene. "Previously we have demonstrated that glucagon receptor mRNA expression in cultured rat hepatocytes and pancreatic islets can be regulated by various factors, including cAMP; however, the regulation of the human glucagon receptor gene has not been well-defined. Here we have characterized the promoter regions of the human glucagon receptor gene," scientists in Copenhagen, Denmark report.

"Primer extension studies yielded multiple products in both liver and pancreas, corresponding to transcription...

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