Gene Therapy
New gene therapy study findings have been reported by scientists at Institute of Biology
Published in Gene Therapy Weekly, June 14th, 2007
Current study results from the report, "The carboxy-terminal region of apoA-I is required for the ABCA1-dependent formation of alpha-HDL but not prebeta-HDL particles in vivo," have been published. According to a study from Agia Paraskevi, Greece, "ATP-binding cassette transporter A-1 (ABCA1)-mediated lipid efflux to lipid-poor apolipoprotein A-I (apoA-I) results in the gradual lipidation of apoA-I. This leads to the formation of discoidal high-density lipoproteins (HDL), which are subsequently converted to spherical HDL by the action of lecithin:cholesterol acyltransferase (LCAT)."
"We have investigated the effect of point mutations and deletions in the...
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Source: Gene Therapy Weekly (2007-06-14)
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