Gene Therapy
Report summarizes gene therapy study findings from Institute of Virology and Immunoprophylaxis
Published in Gene Therapy Weekly, June 21st, 2007
New research, "Toll-like receptor 7 and MyD88 knockdown by lentivirus-mediated RNA interference to porcine dendritic cell subsets," is the subject of a report. "Sensing of viruses by dendritic cell (DC) pathogen recognition receptors (PRRs) represents a critical event during innate antiviral immune responses. Identification of these PRRs has often posed a problem due to difficulties in performing gene function studies in the naturally targeted hosts," scientists in Switzerland report.
"Consequently, we developed a lentivirus (LV)-based strategy for specific gene knockdown in porcine DC. Short hairpin RNAs (shRNAs) were designed, targeting toll-like receptor 7 (TLR7) and...
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Source: Gene Therapy Weekly (2007-06-21)
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