Gene Therapy
Study data from University of Toronto, Department of Medical Biophysics update understanding of gene therapy
Published in Gene Therapy Weekly, June 28th, 2007
A new study, "Hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase," is now available. According to recent research published in the Journal of Biological Chemistry, "The destabilization of endothelial nitric-oxide synthase (eNOS) mRNA in hypoxic endothelial cells may be important in the etiology of vascular diseases, such as pulmonary hypertension. Recently, an overlapping antisense transcript to eNOS/NOS3 was implicated in the post-transcriptional regulation of eNOS."
"We demonstrate here that expression of sONE, also known as eNOS antisense (NOS3AS) or autophagy 9-like 2 (APG9L2), is robustly induced by...
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Source: Gene Therapy Weekly (2007-06-28)
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