Immunology
Scientists at East Tennessee State University, James H. Quillen College of Medicine release new data on immunology
Published in Gene Therapy Weekly, June 28th, 2007
Data detailed in "A novel RBP-Jkappa-dependent switch from C/EBPbeta to C/EBPzeta at the C/EBP binding site on the C-reactive protein promoter" have been presented. According to recent research from the United States, "Regulation of basal and cytokine (IL-6 and IL-1beta)-induced expression of C-reactive protein (CRP) in human hepatoma Hep3B cells occurs during transcription. A critical transcriptional regulatory element on the CRP promoter is a C/EBP binding site overlapping a NF-kappaB p50 binding site."
"In response to IL-6, C/EBPbeta and p50 occupy the C/EBP-p50 site on the CRP promoter. The aim of this study was to identify the transcription factors occupying the...
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Source: Gene Therapy Weekly (2007-06-28)
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