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Research from University of Amsterdam, Swammerdam Institute for Life Sciences reveals new findings on gene therapy

Published in Gene Therapy Weekly, July 5th, 2007

Data detailed in "The three-dimensional structure of human interphase chromosomes is related to the transcriptome map" have been presented. According to a study from Amsterdam, Netherlands, "The three-dimensional (3D) organization of the chromosomal fiber in the human interphase nucleus is an important but poorly understood aspect of gene regulation. Here we quantitatively analyze and compare the 3D structures of two types of genomic domains as defined by the human transcriptome map."

"While ridges are gene dense and show high expression levels, antiridges, on the other hand, are gene poor and carry genes that are expressed at low levels. We show that ridges are in...

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