Gene Therapy
New research on gene therapy from Northeast Normal University, Institute of Genetics and Cytology summarized
Published in Gene Therapy Weekly, July 26th, 2007
Scientists discuss in "The proximal GC-rich region of p16(INK4a) gene promoter plays a role in its transcriptional regulation" new findings in gene therapy. According to recent research from Changchun, People's Republic of China, "P16(INK4a) plays a key role in control of cell cycle progression by negatively regulating the CDK4/6 activity. This study establishes that the p16(INK4a) minimal promoter region required for the transcription factor Sp1 function is mapped at 62 bp upstream of the translation initiation codon."
"This region is GC-rich and shown to interact specifically with Sp1. siRNA-induced Sp1 silencing resulted in the inhibition of the p16(INK4a) minimal...
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Source: Gene Therapy Weekly (2007-07-26)
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