Cancer Vaccines
Research conducted at Y.S. Yang and co-authors has provided new information about cancer vaccines
Published in Gene Therapy Weekly, August 2nd, 2007
According to recent research from Shanghai, People's Republic of China, "Tumor-derived exosomes (TEX) have been proposed as a new kind of cancer vaccine; however, their in vivo antitumor effects are not satisfactory. In order to further improve the efficacy of vaccination with TEX, we investigated whether interleukin-2 (IL-2) genetic modification of tumor cells can make IL-2 presence in the exosomes, thus increasing antitumor effects of the TEX."
"E.G7-OVA tumor cells expressing Ovalbumin (OVA) as a tumor model antigen were used to prepare TEX by serial centrifugation and sucrose gradients ultracentrifugation. To demonstrate their antitumor effects, IL-2-containing...
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Source: Gene Therapy Weekly (2007-08-02)
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