Gene Therapy
Researchers at Umea University publish new data on gene therapy
Published in Gene Therapy Weekly, August 2nd, 2007
"One single-chain Fv antibody fragment (scFv) and a new recombinant covalently linked dimeric scFv antibody (sc(Fv)2) against placental alkaline phosphatase (PLAP) were investigated for selective tumor targeting. The biological behavior of these new antibodies was compared to that of the original native antibody, H7 MAL The sc(Fv)2) antibody displayed convincing tumor localization properties with a rapid excretion pattern comparable to the scFv, but with a longer retention time in the tumor, and higher tumor-to-nontumor ratio (27:1), compared to the scFv (15:1), at 48 hours," scientists writing in the journal Cancer Biotherapy and Radiopharmaceuticals report.
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Source: Gene Therapy Weekly (2007-08-02)
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