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Gene Therapy

New gene therapy data have been reported by scientists at National Institute of Environmental Health Sciences

Published in Gene Therapy Weekly, August 2nd, 2007

Researchers detail in "Proteasome activity modulates chromatin modifications and RNA polymerase II phosphorylation to enhance glucocorticoid receptor-mediated transcription," new data in gene therapy. According to a study from the United States, "The 26S proteasome modulates steroid hormone receptor-dependent gene transcription at least in part by regulating turnover and recycling of receptor/transcriptional DNA complexes, thereby ensuring continued hormone response. For the glucocorticoid receptor (GR), inhibition of proteasome-mediated proteolysis or RNA interference-mediated depletion of specific proteasome subunits results in an increase in gene expression."

"To...

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