Published in Gene Therapy Weekly, August 16th, 2007
"The aim of this study was to investigate the regulation of IL-20 expression in cultured normal human keratinocytes. The expression of IL-20 was rapidly induced by proinflammatory stimuli, in particular IL-1 beta, IL-6, and UVB irradiation. Using kinase inhibitors and small-interfering RNA, we discovered that the p38 mitogen-activated protein kinase (MAPK) as well as inhibitory kappa B kinase -NF-kappa B signaling pathways are crucial for IL-20 expression. By...
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