Gene Therapy

Research from H.R. Drew and co-authors yields new data on Gene Therapy

Published in Gene Therapy Weekly, September 6th, 2007

According to recent research published in the Journal of General Virology, "Adeno-associated virus (AAV) undergoes preferential Rep-mediated integration into the AAVS1 region of human chromosome 19 during latent infection, at least in highly-selected cell cultures. However, integration at the level of the whole eukaryotic genome in unselected cells has not yet been monitored for AAV as it has been for retro- and lentiviruses."

"Here we have used ligation-mediated PCR (LMPCR) to monitor the formation of AAV-chromosome junctions within unselected genomic DNA after infection. Our analyses show that, in the absence of selection, the complexity of junction formation...

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Source: Gene Therapy Weekly (2007-09-06)

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