Gene Therapy
Research from Yale University, Department of Internal Medicine provide new insights into gene therapy
Published in Gene Therapy Weekly, September 6th, 2007
A report, "Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance," is newly published data in Journal of Biological Chemistry. According to recent research from the United States, "Nonalcoholic fatty liver disease (NAFLD) is a major contributing factor to hepatic insulin resistance in type 2 diabetes. Diacylglycerol acyltransferase (Dgat), of which there are two isoforms (Dgat1 and Dgat2), catalyzes the final step in triglyceride synthesis."
"We evaluated the metabolic impact of pharmacological reduction of DGAT1 and -2 expression in liver and fat...
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Source: Gene Therapy Weekly (2007-09-06)
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