Antisense Technology

Data on antisense technology published by researchers at University of Tennessee

Published in Gene Therapy Weekly, September 13th, 2007

According to recent research from the United States, "MicroRNAs (miRNAs) are a recently discovered class of endogenous, small, noncoding RNAs that regulate about 30% of the encoding genes of the human genome. However, the role of miRNAs in vascular disease is currently completely unknown."

"Using microarray analysis, we demonstrated for the first time that miRNAs are aberrantly expressed in the vascular walls after balloon injury. The aberrantly expressed miRNAs were further confirmed by Northern blot and quantitative real-time polymerase chain reaction. Modulating an aberrantly overexpressed miRNA, miR-21, via antisense-mediated depletion (knock-down) had a significant...

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Source: Gene Therapy Weekly (2007-09-13)

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