Gene Therapy

New Gene Therapy study findings have been reported by researchers at Kyoto University, Medical Department

Published in Gene Therapy Weekly, September 13th, 2007

"Death receptor-mediated hepatocyte apoptosis is implicated in a wide range of liver diseases including viral hepatitis, alcoholic hepatitis, ischemia/reperfusion injury, fulminant hepatic failure, cholestatic liver injury, and cancer. Our aim was to clarify the protective pathway in death receptor-mediated hepatocyte apoptosis and the significance of apoptosis in liver injury," scientists in Kyoto, Japan report.

"In vitro: AdI kappa Bsr plus tumor necrosis factor (TNF)-alpha/Jo2 rapidly induced apoptosis in mouse hepatocyte, whereas TNF-alpha/Jo2 alone produced little cytotoxicity. The combination of the mitochondrial permeability transition (MPT) inhibitors,...

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Source: Gene Therapy Weekly (2007-09-13)

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