Gene Therapy

Research conducted at University of Utah has provided new information about Gene Therapy

Published in Gene Therapy Weekly, September 13th, 2007

"Current literature describes several methods for the design of efficient siRNAs with 19 perfectly matched base pairs and 2 nt overhangs. Using four independent databases totaling 3336 experimentally verified siRNAs, we compared how well several of these methods predict siRNA cleavage efficiency," researchers in the United States report.

"According to receiver operating characteristics (ROC) and correlation analyses, the best programs were BioPredsi, ThermoComposition and DSIR. We also studied individual parameters that significantly and consistently correlated with siRNA efficacy in different databases. As a result of this work we developed a new method which utilizes...

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Source: Gene Therapy Weekly (2007-09-13)

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