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Gene Therapy

Scientists at University of Cologne target Gene Therapy

Published in Gene Therapy Weekly, September 13th, 2007

In this recent report published in the journal Molecular Imaging, researchers in Cologne, Germany conducted a study "To develop efficient and safe gene therapy approaches, the herpes simplex virus type 1 thymidine kinase gene (HSV-1-tk) has been shown to function as a marker gene for the direct noninvasive in vivo localization of thymidine kinase (TK) expression by positron emission tomography (PET) using radiolabeled nucleoside analogues as specific TK substrates. Moreover, the gene encoding dopamine type 2 receptor (d2r) could be used as a PET marker gene using specific radiolabeled receptor binding compounds."

"Here we describe the quantitative colocalization...

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