Research from Gifu Pharmaceutical University in the area of gene therapy published

Fresh data on gene therapy are presented in the report "Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage." In this recent report, researchers in Gifu, Japan conducted a study "To clarify whether the activation of double-stranded RNA-dependent protein kinase (PKR) participates in the cell death induced by endoplasmic reticulum (ER) stress, the authors used cultured retinal ganglion cells (RGC-5, a rat ganglion cell line transformed with the E1A virus) in vitro and the effect of a PKR inhibitor (an imidazolo-oxindole derivative) on N-methyl-D-aspartate (NMDA)-induced retinal damage in mice in vivo. In RGC-5 culture, cell damage was...

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