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Spectroscopy

Researchers from Johann Wolfgang Goethe University, Institute for Organic Chemistry and Chemical Biology discuss findings in spectroscopy

Published in Gene Therapy Weekly, September 27th, 2007

Researchers detail in "Quantitative Gamma-HCNCH: determination of the glycosidic torsion angle chi in RNA oligonucleotides from the analysis of CH dipolar cross-correlated relaxation by solution NMR spectroscopy," new data in spectroscopy. "A novel NMR pulse sequence is introduced to determine the glycosidic torsion angle chi in (13)C,(15)N-labeled oligonucleotides. The quantitative Gamma-HCNCH measures the dipolar cross-correlated relaxation rates Gamma(DD,DD)(C8H8,C1'H1') (pyrimidines) and Gamma(DD,DD)(C6H6,C1'H1') (purines)," scientists in Frankfurt, Germany report.

"Cross-correlated relaxation rates of a (13)C,(15)N-labeled RNA 14mer containing a cUUCGg tetraloop...

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