Published in Gene Therapy Weekly, September 27th, 2007
"The present study elucidates the potential to use herpes simplex virus (HSV) derived vectors for expression of antisense RNA to HPV-16 E7 oncogene. We have constructed replication competent, nonneuroinvasive HSV-1 vectors, deleted of the gamma(1)34.5 gene. The vectors express RNA antisense to the first 100 nucleotides of the HPV-16 E7 gene. We assayed the ability of the antisense E7 vectors...
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