Research from University of Missouri provide new insights into prodrugs

"The aim of this study is to investigate the roles of the lactide/glycolide ratio and prodrug derivatization on the in vitro release of ganciclovir and its lipophilic prodrug (GCV-monobutyrate) from PLGA microspheres for the treatment of cytornegalovirus (CMV) retinitis. Two grades of PLGA, a higher lactide content PLGA 6535 [D,L-lactide: glycolide = 65:35, MW 45,000-75,000 Da] and lower lactide content PLGA 5050 [D,L-lactide:glycolide = 50:50, MW 45,000-75,000 Da] were employed to prepare GCV loaded microspheres. The effect of lipophilic prodrug derivatization was investigated by converting GCV to GCV-monobutyrate (GCVMB)," scientists in the United States report.

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