Leukemia
Reports on leukemia findings from German Cancer Research Center provide new insights
Published in Gene Therapy Weekly, October 4th, 2007
Investigators publish new data in the report "Efficient nucleofection of primary human B cells and B-CLL cells induces apoptosis, which depends on the microenvironment and on the structure of transfected nucleic acids." According to recent research from Heidelberg, Germany, "Accumulation of neoplastic cells in B-cell chronic lymphocytic leukemia (B-CLL) is thought to be due to intrinsic defects in the apoptotic machinery of the leukemic cells or to an altered, survival-stimulating microenvironment in vivo. Despite their long survival in vivo, B-CLL cells undergo rapid spontaneous apoptosis ex vivo."
"To maintain survival in vitro, we established a coculture system using...
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Source: Gene Therapy Weekly (2007-10-04)
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