Published in Gene Therapy Weekly, October 4th, 2007
"Conversely, TGF beta generates a permissive environment for cancer growth, in part by antagonizing the effects of immunomodulatory cytokines, including IL-12. We demonstrate that TGF beta-resistant T cells are capable of sustaining IL-12-induced mitogenesis and interferon-gamma secretion in a TGF beta-rich milieu. Furthermore, in 2 murine tumor...
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