Cancer Gene Therapy
T vs. B: Re-engineered Human T Cells Effectively Target and Kill Cancerous B Cells
Published in Gene Therapy Weekly, October 4th, 2007
Human white blood cells, engineered to recognize other malignant immune cells, could provide a novel therapy for patients with highly lethal B cell cancers such as acute lymphoblastic leukemia (ALL), according to researchers at Memorial Sloan-Kettering Cancer Center (MSKCC). By administering repeated doses of T cells designed to express an artificial receptor which recognizes human B cells, the researchers were able to eradicate cancer in 44 percent of mice bearing human ALL tumors.
Their findings, published in the September 15 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, show that modified T cells – the white blood cells...
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Source: Gene Therapy Weekly (2007-10-04)
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