Gene Therapy
Research from University of California, Cancer Center provides new data on gene therapy
Published in Gene Therapy Weekly, October 4th, 2007
Fresh data on gene are presented in the report "Pol eta is required for DNA replication during nucleotide deprivation by hydroxyurea. Hydroxyurea reduces DNA replication by nucleotide deprivation, whereas UV damage generates DNA photoproducts that directly block replication fork progression. We show that the low fidelity class Y polymerase Pol eta is recruited to proliferating cell nuclear antigen at replication forks both by hydroxyurea and UV light," researchers in the United States report.
"Under nucleotide deprivation, Pol eta allows cells to accumulate at the G1/S boundary by facilitating slow S-phase progression and promotes apoptosis. Normal cells consequently...
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Source: Gene Therapy Weekly (2007-10-04)
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