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Cancer Vaccines

Research from INSERM has provided new data on cancer vaccines

Published in Gene Therapy Weekly, October 11th, 2007

"In human pancreatic adenocarcinoma, alterations of glycosylation processes leads to the expression of tumor-associated carbohydrate antigens, representing potential targets for cancer immunotherapy. Among these pancreatic tumor-associated carbohydrate antigens, the J28 glycotope located within the O-glycosylated mucin-like C-terminal domain of the fetoacinar pancreatic protein (FAPP) and expressed at the surface of human tumoral tissues, can be a good target for anticancer therapeutic vaccines," scientists in Marseille, France report.

"However, the oncodevelopmental self character of the J28 glycotope associated with the low immunogenicity of tumor-associated...

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