Published in Gene Therapy Weekly, October 18th, 2007
"In pathological situations, astrocytes are activated but the consequences on brain energy metabolism are still poorly characterized. We found that local lentiviral-mediated gene transfer of ciliary neurotrophic factor (CNTF), a cytokine known to activate astrocytes, induced a stable decrease in the glycolytic flux in the rat striatum in vivo as measured by 2-[F-18]2-deoxy-D-glucose autoradiography and micro-positron emission tomography imaging. The...
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