Nanotechnology

New nanotechnology research reported from University of Strathclyde

Published in Gene Therapy Weekly, October 18th, 2007

"Metallic nanoparticles of gold functionalized with oligonucleotides conventionally use a terminal thiol modification and have been used in a wide range of applications. Although readily available, the oligonucleotide-nanoparticle conjugates prepared in this way suffer from a lack of stability when exposed to a variety of small molecules or elevated temperatures," researchers in Scotland report.

"If silver is used in place of gold then this lack of stability is even more pronounced. In this study we report the synthesis of highly stabilized oligonucleotide-nanoparticle conjugates using a simple oligonucleotide modification. A modified solid support was used to generate...

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Source: Gene Therapy Weekly (2007-10-18)

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