Gene Therapy

Reports outline gene therapy research from Leiden University

Published in Gene Therapy Weekly, November 1st, 2007

Researchers detail in 'Optimization of short-term transgene expression by sodium butyrate and ubiquitous chromatin opening elements (UCOEs),' new data in gene therapy. According to a study from Leiden, Netherlands, "' Predictable and adequate transgene expression is essential for clinical gene therapy. Several studies have focused on optimization of transgene expression."

"In this study the effect of sodium butyrate (NaB) and a ubiquitous chromatin opening element (UCOE) on short-term gene expression after adenovirus-mediated gene transfer in fibroblastic interface cells from periprosthetic tissue in loosened orthopedic implants is investigated. Cultures of diploid...

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Source: Gene Therapy Weekly (2007-11-01)

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