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Molecular Systems

Study findings from Forschungszentrum Karlsruhe GmbH broaden understanding of molecular systems

Published in Gene Therapy Weekly, November 8th, 2007

"Motility is achieved in most bacterial species by the flagellar apparatus. It consists of dozens of different proteins with thousands of individual subunits," scientists in Karlsruhe, Germany report.

"The published literature about bacterial chemotaxis and flagella documented 51 protein-protein interactions (PPIs) so far. We have screened whole genome two-hybrid arrays of Treponema pallidum and Campylobacter jejuni for PPIs involving known flagellar proteins and recovered 176 and 140 high-confidence interactions involving 110 and 133 proteins, respectively. To explore the biological relevance of these interactions, we tested an Escherichia coli gene deletion array for...

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