Gene Therapy
Findings in gene therapy reported from University of Florida, Department of Molecular Genetics
Published in Gene Therapy Weekly, November 8th, 2007
Fresh data on gene are presented in the report 'SOD2 knockdown mouse model of early AMD.' According to recent research from the United States, " To test the hypothesis that oxidative injury to the retinal pigment epithelium (RPE) may lead to retinal damage similar to that associated with the early stages of age-related macular degeneration (AMD). A ribozyme that targets the protective enzyme manganese superoxide dismutase (MnSOD) was expressed in RPE-J cells, and adeno-associated virus (AAV) expressing the ribozyme gene was injected beneath the retinas of adult C57BL/6 mice."
"The RPE/choroid complex was examined for SOD2 protein levels and protein markers of oxidative...
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Source: Gene Therapy Weekly (2007-11-08)
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