Gene Therapy
New gene therapy data have been reported by researchers at University of Tokushima
Published in Gene Therapy Weekly, November 8th, 2007
New investigation results, 'Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression,' are detailed in a study published in Gene. According to a study from Tokushima, Japan, "PACE4, a member of the subtilisin-like proprotein convertase (SPC) family, is expressed at high levels in certain tumor cells and plays a role in metastatic progression through activation of matrix metalloproteinases. The mechanism leading to overexpression of PACE4 in tumor cells remains unclear."
"In this study, we show that the E2F1 transcription factor, which is implicated in carcinoma...
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Source: Gene Therapy Weekly (2007-11-08)
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