Breast Cancer Genetics
Research conducted at University of Chicago, Center for Metastasis Research has updated our knowledge about breast cancer genetics
Published in Gene Therapy Weekly, November 15th, 2007
New research, 'RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors,' is the subject of a report. "The breast cancer susceptibility gene BRCA1 encodes a large protein thought to contribute to a variety of cellular processes, although the critical determinants of BRCA1-deficient tumorigenesis remain unclear. Given that BRCA1 is required for cell proliferation, suppressor mutations are believed to modify BRCA1 phenotypes and contribute to the etiology of BRCA1-deficient tumors," scientists in the United States report.
"Here, we show that overexpression of the homologous recombinase RAD51 in a DT40 BRCA1Delta/Delta mutant...
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Source: Gene Therapy Weekly (2007-11-15)
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